Role of O-acetyltransferase in activation of oxidised metabolites of the genotoxic environmental pollutant 1-nitropyrene

PF Rosser, P Ramachandran, R Sangaiah…

Index: Rosser; Ramachandran; Sangaiah; Austin; Gold; Ball Mutation Research - Genetic Toxicology, 1996 , vol. 369, # 3-4 p. 209 - 220

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Citation Number: 16

Abstract

The genotoxic environmental contaminant 1-nitropyrene is metabolised in mammalian systems by pathways more complex than the straightforward nitroreduction which accounts for most of its biological activity in bacteria. In order to evaluate the role of O- acetyltransferase (OAT) activity in generation of genotoxic intermediates from 1-nitropyrene, the mutagenecity of the major primary oxidised metabolites of 1-nitropyrene was ...