Synthesis and reactivity of non-activated 2-(chloromethyl) aziridines

S Stanković, M D'hooghe, J Dewulf, P Bogaert…

Index: Stankovic, Sonja; D'Hooghe, Matthias; Dewulf, Jo; Bogaert, Piet; Jolie, Robrecht; De Kimpe, Norbert Tetrahedron Letters, 2011 , vol. 52, # 35 p. 4529 - 4532

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Citation Number: 4

Abstract

An efficient synthesis of non-activated 2-(chloromethyl) aziridines and 2-chloromethyl-2- methylaziridines as new representatives of the class of 2-(halomethyl) aziridines was developed. Furthermore, the reactivity of these azaheterocycles was assessed and compared to that of their brominated counterparts, pointing to a similar profile for 2- (chloromethyl) aziridines and 2-(bromomethyl) aziridines on the one hand, and a different ...