Stereoselective synthesis of 3, 3-diarylacrylonitriles as tubulin polymerization inhibitors

…, Y Song, T Sarkar, E Hamel, WE Fogler…

Index: Fang, Zhenglai; Song, Yunlong; Sarkar, Taradas; Hamel, Ernest; Fogler, William E.; Agoston, Gregory E.; Fanwick, Phillip E.; Cushman, Mark Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4241 - 4244

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Citation Number: 15

Abstract

A series of 3, 3-diarylacrylonitriles were synthesized stereoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3, 3-diarylacrylonitriles to be prepared in a very short sequence of reactions.

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