Flexible total synthesis of biphenomycin B
H Waldmann, YP He, H Tan, L Arve…
Index: Waldmann, Herbert; He, Yu-Peng; Tan, Hao; Arve, Lars; Arndt, Hans-Dieter Chemical Communications, 2008 , # 43 p. 5562 - 5564
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Citation Number: 16
Abstract
A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki–Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity.
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