Stereoselective synthesis of 9-hydroxyellipticine glycosides, novel and highly active antitumor agents.

…, M Inoue, M Kato, K Shima, T Shimamoto

Index: Honda; Inoue; Kato; Shima; Shimamoto Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 9 p. 3975 - 3978

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Citation Number: 12

Abstract

A series of novel and highly active antitumor agents, 9-hydroxyellipticine glycosides were stereoselectively synthesized in good yields by an improved condensation reaction between 9-acetoxyellipticine and peracylated glycosyl halides using cadmium carbonate, followed by the removal of acyl groups with methanolic ammonia.