A simple total synthesis of the isoindolobenzazepine alkaloids lennoxamine and chilenamine
E Napolitano, G Spinelli, R Fiaschi…
Index: Napolitano, Elio; Spinelli, Guido; Fiaschi, Rita; Marsili, Antonio Synthesis, 1985 , # 1 p. 38 - 40
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Citation Number: 19
Abstract
Lennoxamine () and chilenamine () have been synthesized from 3-(3, 4- methylenedioxybenzylidene)-6, 7-dimethoxyphthalide () in four and five high-yielding steps, respectively. The key step of the process is the cyclization, by intramolecular alkylation, of 3- (3, 4-methylenedioxybenzyl)-6, 7-dimethoxyphthalimidin-2-ylacet
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