A new spirocyclic proline-based lactam as efficient type II′ β-turn inducing peptidomimetic

G Lesma, A Colombo, A Sacchetti, A Silvani

Index: Lesma, Giordano; Colombo, Alessia; Sacchetti, Alessandro; Silvani, Alessandra Tetrahedron Letters, 2008 , vol. 49, # 52 p. 7423 - 7425

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Citation Number: 14

Abstract

A new proline-based spirotricyclic lactam is reported as an efficient type II′ β-turn inducing peptidomimetic. After investigations of the reverse turn properties by computational techniques, the scaffold has been synthesized by a straightforward sequence relying on a key RCM reaction for the construction of the spirocyclic lactams ring. For its conformational properties, the scaffold can be considered a privileged structure to be employed as a ...