Directed Magnesiation of Polyhaloaromatics using the Tetramethylpiperidylmagnesium Reagents TMP2Mg⋅ 2 LiCl and TMPMgCl⋅ LiCl

…, CJ Rohbogner, P Knochel

Index: Unsinn, Andreas; Rohbogner, Christoph J.; Knochel, Paul Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1553 - 1560

Full Text: HTML

Citation Number: 9

Abstract

Abstract A convenient and efficient functionalization of polyhaloaromatics via regioselective magnesiation has been developed. Starting from simple, inexpensive but structurally challenging arenes, metallation by magnesium amide bases was achieved under mild conditions. The desired Grignard reagents were stable towards aryne formation, were obtained in good yields within short reaction times and could be reacted with a variety of ...