The Journal of Organic Chemistry

Synthesis of 4-aryl-3, 5-bis (alkoxycarbonyl)-1, 4-dihydropyrazines

RJ Chorvat, KJ Rorig

Index: Chorvat, Robert J.; Rorig, Kurt J. Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5779 - 5781

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Citation Number: 89

Abstract

Our approach to this series'(Scheme I) proceeded from the aniline NJV-bis (alky1 acetates) 5aa and 5b. The latter nitroaniline derivative was prepared from 4b by treatment with ethyl diazoacetate in refluxing benzene in the presence of a catalytic amount of rhodium acetate dimer. g Functionalization of both methylene groups of these ester appendages was accomplished using either bis (dimethy1-amin0) methoxymethane in the case of 5a or tris ...