Journal of Fluorine Chemistry

Selective mono-fluorination of diols via a cyclic acetal of N, N-diethyl-4-methoxybenzamide

M Suwada, T Fukuhara, S Hara

Index: Suwada, Mitsuhiro; Fukuhara, Tsuyoshi; Hara, Shoji Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1121 - 1125

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Citation Number: 3

Abstract

Selective mono-fluorination of 1, 2-and 1, 3-diols was achieved using N, N-diethyl-4- methoxybenzamide diethyl acetal and Et3N-3HF. The reaction proceeds through a cyclic acetal of the benzamide, and only one hydroxy group was fluorinated and another one was acylated.