Regioselective synthesis of sterically encumbered diaryl ethers based on one-pot cyclizations of 4-aryloxy-1, 3-bis (trimethylsilyloxy)-1, 3-dienes
…, H Reinke, A Spannenberg, C Fischer, P Langer
Index: Rashid, Muhammad A.; Rasool, Nasir; Adeel, Muhammad; Reinke, Helmut; Spannenberg, Anke; Fischer, Christine; Langer, Peter Tetrahedron, 2008 , vol. 64, # 3 p. 529 - 535
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Citation Number: 6
Abstract
Functionalized diaryl ethers are of pharmacological relevance and occur in a variety of natural products. 1 This includes, for example, geodinhydrate methylester, methyl chloroasterrate, 2, 2a and 2b 1-desgalloylsanguiin, 2c dehydrotrigallic acid, 2d epiphorellic acid, 2e jolkianin, 2f remurin A 2g and micareic acid (Scheme 1). 2h The most important approach to diaryl ethers relies on the Ullmann 3, 3a and 3b and Buchwald–Hartwig 4 reaction and on related ...
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