Synthesis and Evaluation of Antiinflammatory and Analgesic Activities of a Novel Series of Substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides

PM Ronad, RD Hunashal, S Darbhamalla…

Index: Ronad, Pradeepkumar M.; Hunashal, Rajesh D.; Darbhamalla, Satyanarayana; Maddi, Veeresh S. Arzneimittel-Forschung/Drug Research, 2008 , vol. 58, # 12 p. 641 - 646

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Citation Number: 11

Abstract

Abstract A novel series of coumarinyl amides (IVa-1) have been synthesized by reacting 7- amino-4-methylcoumarin (III) with various substituted aromatic acid chlorides. IR, 1 H NMR, 13 C NMR and HRMS spectral data characterized the structure of the synthesized compounds. The title compounds were screened for in vivo acute anti-inflammatory activity using the carrageenan-induced rat paw edema assay model. Among the compounds ...