Journal of medicinal chemistry

Isoxazole anthelmintics

JB Carr, HG Durham, DK Hass

Index: Carr,J.B. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 934 - 939

Full Text: HTML

Citation Number: 54

Abstract

Hydrogenolysis of a mixture of 18a and 18b as described above gave a mixture of 2a and 2b as a colorless glass (90%): TLC (10% MeOHCHC13) shows two bands at lower R, than starting material; IR and'H NMR as expected; attempts to crystallize the mixture were unsuccessful. The diastereomers were separated by preparative TLC (20% MeOHCHClJ, giving hygroscopic glasses. The greater R, diastereomer was designated 2b:[a] 25589- ...