Synthesis

Synthesis of novel conformationally constrained pyrazolo [4, 3-c] quinoline derivatives as potential ligands for the estrogen receptor

KM Kasiotis, N Fokialakis, SA Haroutounian

Index: Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A. Synthesis, 2006 , # 11 p. 1791 - 1802

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Citation Number: 6

Abstract

Abstract The preparation of three novel classes of pyrazolo [4, 3-c] quinoline derivatives is reported. The easily accessible 2, 3-dihydro-1H-quinolin-4-ones were used as the starting materials and were functionalized with three different acylating agents affording their respective constrained core substrates. The latter by condensation with phenyl (or 4- methoxyphenyl) hydrazines and subsequent debenzylation or demethylation provided the ...