New Highly Asymmetric Henry Reaction Catalyzed by CuII and a C1??Symmetric Aminopyridine Ligand, and Its Application to the Synthesis of Miconazole

…, LR Domingo, V Hernández??Olmos…

Index: Blay, Gonzalo; Domingo, Luis R.; Hernandez-Olmos, Victor; Pedro, Jose R. Chemistry - A European Journal, 2008 , vol. 14, # 15 p. 4725 - 4730

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Citation Number: 132

Abstract

Abstract A new catalytic asymmetric Henry reaction has been developed that uses a C 1- symmetric chiral aminopyridine ligand derived from camphor and picolylamine. A variety of aromatic, heteroaromatic, aliphatic, and unsaturated aldehydes react with nitromethane and other nitroalkanes in the presence of DIPEA (1.0 equiv), Cu (OAc) 2⋅ H 2 O (5 mol%), and an aminopyridine ligand (5 mol%) to give the expected products in high yields (up to 99%) ...