Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1, 3-dicarboxylic acid, and related phosphonic and carboxylic acids

…, TW Hambley, GAR Johnston, KN Mewett…

Index: Allan, Robin D.; Hanrahan, Jane R.; Hambley, Trevor W.; Johnston, Graham A. R.; Mewett, Kenneth N.; Mitrovic, Ann D. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2905 - 2915

Full Text: HTML

Citation Number: 96

Abstract

7a R= H, cis 7b RH, frans 13 R-COzH (a) Hz, 10% Pd/C, EtOH;(b) RuO,, NaI04, HzO, CCl,;(c)(i) KOH, HzO, EtOH,(ii) 6 M HCl;(d)(i)", OH, KCN, NH, Cl, H20,(ii) 6 M HCl;(e)(i)", OH," ammonium carbonate", KCN, H20, MeOH,(ii) 6 M HC1;(f)(i) 0.5 M NaOH, reflux,(ii) 6 M HCl. are also under investigation as antileptic16 and anticonvulsant age~~ ts.'~ J~ A considerable number of potent and selective NMDA antagonists have become available ...