Total synthesis of the aspercyclides

J Pospíšil, C Müller, A Fürstner

Index: Pospisil, Jiri; Mueller, Christoph; Fuerstner, Alois Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5956 - 5968

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Citation Number: 43

Abstract

Abstract Disparate sister compounds: Despite their similarity, significantly different strategies were necessary to bring the individual members of the aspercyclide family into reach. Whereas the strained eleven-membered ring of aspercyclide C (see figure) could be closed by RCM, it required the power of organochromium chemistry (Nozaki–Hiyama–Kishi reaction) to forge the frame of its sterically even more hindered congener aspercyclide B.