Journal of medicinal chemistry

Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme

AS Madsen, CA Olsen

Index: Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

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Citation Number: 29

Abstract

The class III lysine deacylases (KDACs), also known as the sirtuins, have emerged as interesting drug targets for therapeutic intervention in a variety of diseases. To gain a deeper understanding of the processes affected by sirtuins, the development of selective small molecule modulators of individual isozymes has been a longstanding goal. Essential for the discovery of novel modulators, however, are good screening protocols and mechanistic ...