Helvetica chimica acta

One??Pot Three??Component Synthesis of α??Amino Nitriles Catalyzed by 2, 4, 6??Trichloro??1, 3, 5??triazine (Cyanuric Acid)

B Das, RA Kumar, P Thirupathi

Index: Das, Biswanath; Kumar, Rathod Aravind; Thirupathi, Ponnaboina Helvetica Chimica Acta, 2007 , vol. 90, # 6 p. 1206 - 1210

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Citation Number: 14

Abstract

Introduction. – α-Amino nitriles are important intermediates in the preparation of amino acids [1] and various nitrogen heterocycles [2] such as imidazoles and thiadiazoles. They are generally prepared by nucleophilic addition of the cyanide anion (CNÀ) to imines (Strecker-type reaction). Several modifications of the Strecker reaction have been reported with a variety of cyanating agents such as HCN [3], KCN [4], Et2AlCN [5], (EtO)2P(O)CN [6], Bu3SnCN [7], ...