Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase

I Abe, T Abe, K Wanibuchi, H Noguchi

Index: Abe, Ikuro; Abe, Tsuyoshi; Wanibuchi, Kiyofumi; Noguchi, Hiroshi Organic Letters, 2006 , vol. 8, # 26 p. 6063 - 6065

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Citation Number: 37

Abstract

Benzalacetone synthase from Rheum palmatum efficiently catalyzed condensation of N- methylanthraniloyl-CoA (or anthraniloyl-CoA) with malonyl-CoA (or methylmalonyl-CoA) to produce 4-hydroxy-2 (1 H)-quinolones, a novel alkaloidal scaffold produced by a type III polyketide synthase (PKS). Manipulation of the functionally divergent type III PKSs by a nonphysiological substrate thus provides an efficient method for production of ...