Tetrahedron

Solid-phase synthesis of 6-hydroxy-2, 4-diaminoquinazolines

…, Á Demeter, I Borza, GI Szendrei, GM Keserű, I Greiner

Index: Weber, Csaba; Bielik, Attila; Demeter, Adam; Borza, Istvan; Szendrei, Gyoergyi I.; Keseru, Gyoergy M.; Greiner, Istvan Tetrahedron, 2005 , vol. 61, # 39 p. 9375 - 9380

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Citation Number: 9

Abstract

A new method for the solid-phase synthesis of 6-hydroxy-2, 4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound 6-hydroxy-2, 4- dichloroquinazoline as a key intermediate. Sequential substitution of the two chlorines furnishes the title compounds regioselectively with high purity. A library of 18× 22 compounds demonstrates the general utility of this approach.