Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228
…, JA Restituyo, RJ Katzenberger, DA Wassarman…
Index: Mays, Jared R.; Restituyo, Jose A.; Katzenberger, Rebeccah J.; Wassarman, David A.; Rajski, Scott R. Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4579 - 4583
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Citation Number: 11
Abstract
Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition. ... The synthesis and preliminary ...
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