Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R, 5R, 6R)-4, 5, 6-trihydroxycyclohex-2- …
CL Arthurs, J Raftery, HL Whitby, RC Whitehead…
Index: Arthurs, Claire L.; Raftery, James; Whitby, Helen L.; Whitehead, Roger C.; Wind, Natasha S.; Stratford, Ian J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5974 - 5977
Full Text: HTML
Citation Number: 19
Abstract
The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2- crotonyloxymethyl-(4R, 5R, 6R)-4, 5, 6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented.
Related Articles:
Chemoenzymatic enantiodivergent synthesis of 1, 2-dideoxy-2-amino-1-fluoro-allo-inositol
[Oppong, Kofi A.; Hudlicky, Tomas; Yan, Fengyang; York, Chentao; Nguyen, Ba V. Tetrahedron, 1999 , vol. 55, # 10 p. 2875 - 2880]
A practical multigram-scale synthesis of allo-inositol
[Desjardins, Michel; Brammer Jr., Larry E.; Hudlicky, Tomas Carbohydrate Research, 1997 , vol. 304, # 1 p. 39 - 42]
A practical multigram-scale synthesis of allo-inositol
[Desjardins, Michel; Brammer Jr., Larry E.; Hudlicky, Tomas Carbohydrate Research, 1997 , vol. 304, # 1 p. 39 - 42]
[Hudlicky, Tomas; Claeboe, Christopher D.; Brammer Jr., Larry E.; Koroniak, Lukasz; Butora, Gabor; Ghiviriga, Ion Journal of Organic Chemistry, 1999 , vol. 64, # 13 p. 4909 - 4913]
[Finn, Kevin J.; Collins, Jonathan; Hudlicky, Tomas Tetrahedron, 2006 , vol. 62, # 31 p. 7471 - 7476]