Novel hexadentate and pentadentate chelators for 64 Cu-based targeted PET imaging
I Sin, CS Kang, N Bandara, X Sun, Y Zhong…
Index: Sin, Inseok; Kang, Chi Soo; Bandara, Nilantha; Sun, Xiang; Zhong, Yongliang; Rogers, Buck E.; Chong, Hyun-Soon Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2553 - 2562
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Abstract
Abstract A series of new hexadentate and pentadentate chelators were designed and synthesized as chelators of 64 Cu. The new pentadentate and hexadentate chelators contain different types of donor groups and are expected to form neutral complexes with Cu (II). The new chelators were evaluated for complex kinetics and stability with 64 Cu. The new chelators instantly bound to 64 Cu with high labeling efficiency and maximum specific ...
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