Modification of receptor selectivity and functional activity of cyclic cholecystokinin analogues

M Amblard, M Rodriguez, MF Lignon, MC Galas…

Index: Amblard, Muriel; Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Bernad, Nicole; Aumelas, Andre; Martinez, Jean European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 171 - 180

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Citation Number: 3

Abstract

We reported earlier on the synthesis and biological activity at the CCK-B receptor of cyclized derivatives of CCK. These peptides, in which the positions 28 and 31 were replaced by lysine residues, were bridged by a succinyl moiety. To determine the importance of the nature and size of the cyclic structure, cyclic analogues were synthesized in which:(i) the lysine residues were replaced by ornithine and diaminobutyric acid and (ii) the succinic ...