J. Chem. Res.(S)

A Convenient Access to 1, 1-Difluoroethyl Triflate and Iodide†

L Marival-Hodebar, M Tordeux, C Wakselman

Index: Marival-Hodebar, Laurence; Tordeux, Marc; Wakselman, Claude Journal of Chemical Research - Part S, 1998 , # 4 p. 192 - 193

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Abstract

The synthesis of compounds bearing two fluorine atoms on the same carbon is of great importance owing to their chemical and biological properties. However, few methods are known for the functionalization of RCF2X compounds (X = H, halogen).1 1,1-Difluoro-1-iodoethane is currently prepared from 1,1-difluoroethylene and hydrogen iodide [eqn. (1)]. On a small scale, the reaction is very slow; however, it is very fast and exothermic on a larger scale but requires complex ...