Efficient Synthetic Approach to Fluorescent Oxazole-4-carboxylate Derivatives

…, KA Lukyanov, PE Ivashkin, IV Yampolsky

Index: Baranov, Mikhail S.; Lukyanov, Konstantin A.; Ivashkin, Pavel E.; Yampolsky, Ilia V. Synthetic Communications, 2013 , vol. 43, # 17 p. 2337 - 2342

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Citation Number: 4

Abstract

In our attempt to synthesize a halogenated analog of green fluorescent protein (GFP) chromophore, we discovered a simple and efficient synthetic strategy to the derivatives of oxazole-4-carboxylic acid substituted at positions 2 and 5. The method allows for introduction of different aryl substituents at the position 5, aryl or alkyl substituents at position 2 of oxazole, and gives access not only to free carboxyl at position 4, but also to a range of its ...