Synthesis of the 'Northern-Hemisphere'Fragments of the Thiopeptide Antibiotic Nosiheptide
T Belhadj, A Nowicki, CJ Moody
Index: Belhadj, Tahar; Nowicki, Audrey; Moody, Christopher J. Synlett, 2006 , # 18 p. 3033 - 3036
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Citation Number: 6
Abstract
The modified glutamate 4, corresponding to fragment D in the original analysis, has been synthesized on four previous occasions: from d-glucose (ca. 12 steps), [13] from (S)-2,2-dimethyl-1,3-dioxolane -4-acetaldehyde (10 steps, overall yield ca. 11%), [15] from (S)-pyroglutamic acid (11 steps, overall yield ca. 2%), [14] or from d-glyceraldehyde (11 steps, overall yield ca. 8%). [14] Our route that starts from commercially available N-Boc-glutamic acid benzyl ester 7 delivers the ...
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