Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-. beta.-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives

…, T Takeda, T Sasaki, A Matsuda, T Ueda

Index: Minakawa; Takeda; Sasaki; Matsuda; Ueda Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 778 - 786

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Citation Number: 52

Abstract

Scheme I" antiallergic and hypotensive activity of 2-alkynyladenosines has been reported by us and it was found that the presence of the triple bond is essential for the activities." 4'- Ethynylthymidine inhibits herpes simplex type 1 induced thymidine kinase.'* Thus, an alkynyl functional group attached to certain nucleosides would have interesting characteristics. In this paper, we describe the syntheses of 5-alkynyl-lP-~-ribofuranosylimidazole-4- ...