Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E

…, MM Domostoj, B Scheiper

Index: Fuerstner, Alois; Domostoj, Mathias M.; Scheiper, Bodo Journal of the American Chemical Society, 2006 , vol. 128, # 24 p. 8087 - 8094

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Citation Number: 76

Abstract

Concise and flexible total syntheses of the pyrrolo [2, 3-c] carbazole alkaloids dictyodendrin B (2), C (3), and E (5) are described. These polycyclic telomerase inhibitors of marine origin derive from the common intermediate 18 which was prepared on a multigram scale by a sequence comprising a TosMIC cycloaddition with formation of the pyrrole A-ring, a titanium- induced reductive oxoamide coupling reaction to generate an adjacent indole nucleus, ...