A practical synthesis of the ansa chain of benzenic ansamycin antibiotics: Total synthesis of an ansatrienol derivative

D Kashin, A Meyer, R Wittenberg, KU Schöning…

Index: Synthesis, , # 2 p. 304 - 319

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Citation Number: 13

Abstract

... 4 The Aromatic Building Block. Scheme 6 Synthesis of aromatic building block 7. Reagents and conditions: (a) MeI, Ag 2 O, CH 2 Cl 2 , 40 °C, 3 h, 73%; (b) NaBH 4 , MeOH, 0 °C, 1 h, 92%; (c) Ph 3 P, CBr 4 , Et 2 O, 0 °C, 1 h then rt, 2 h, 86%; (d) PhSO 2 Na, DMF, 50 °C, 14 h ...