Preparation and stability of ethanol??free solution of [18F] florbetapir ([18F] AV??45) for positron emission tomography amyloid imaging

…, A Tachibana, S Tazawa, Y Mizukawa…

Index: Hayashi, Kazutaka; Tachibana, Akiko; Tazawa, Shusaku; Mizukawa, Yosuke; Osaki, Katsuhiko; Morimoto, Yoko; Zochi, Riyo; Kurahashi, Masahiro; Aki, Hatsumi; Takahashi, Kazuhiro Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 5 p. 295 - 300

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Citation Number: 3

Abstract

We have developed an ethanol-free formulation method of [18F] florbetapir ([18F] AV-45) using a commercially available automated JFE multi-purpose synthesizer. We have also evaluated the radiochemical stability in an ethanol-free solution of [18F] AV-45 under visible light irradiation and dark conditions by comparison with a conventional 10% ethanol solution of [18F] AV-45.[18F] AV-45 was obtained with a radiochemical yield of 55.1 Æ 2.2%(decay ...