Facile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl) ethoxyacetylene
…, S Akai, N Ajimura, M Yoshigi, T Tsugoshi…
Index: Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al. Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
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Citation Number: 102
Abstract
(Trimethylsilyl) ethoxyacetylene, a stable and easy-handling reagent, serves as an excellent dehydrating agent for the synthesis of carboxylic anhydrides and amides from the corresponding carboxylic acids. By means of this reagent, various types of acid-sensitive carboxylic anhydrides and amides were obtained almost in quantitative yields. Twenty-two examples of carboxylic anhydrides and 12 examples of amides were presented.
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