Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

…, S Suy, K Wang, S Dakshanamurthy, A Cordova…

Index: Davis, Gary C.; Kong, Yali; Paige, Mikell; Li, Zhang; Merrick, Ellen C.; Hansen, Todd; Suy, Simeng; Wang, Kan; Dakshanamurthy, Sivanesan; Cordova, Antoinette; McManus, Owen B.; Williams, Brande S.; Chruszcz, Maksymilian; Minor, Wladek; Patel, Manoj K.; Brown, Milton L. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2180 - 2188

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Citation Number: 11

Abstract

Voltage-gated sodium channels are known to be expressed in neurons and other excitable cells. Recently, voltage-gated sodium channels have been found to be expressed in human prostate cancer cells. α-Hydroxy-α-phenylamides are a new class of small molecules that have demonstrated potent inhibition of voltage-gated sodium channels. The hydroxyamide motif, an isostere of a hydantoin ring, provides an active scaffold from which several potent ...