Journal of fluorine chemistry

Direct fluorination of aryl ketone hydrazones

TB Patrick, PA Flory

Index: Patrick,T.B.; Flory,P.A. Journal of Fluorine Chemistry, 1984 , vol. 25, p. 157

Full Text: HTML

Citation Number: 13

Abstract

Abstract The hydrazones of benzophenone, acetophenone, and deoxybenzoin react with dilute fluorine to produce intermediate diazo compounds which react further with the fluorine or nascent hydrogen fluoride to give geminal difluoro or monofluoro derivatives respectively of the starting hydrazones. The fluorination procedure has been applied to two biological systems, 1 and 2, with their conversion to monofluoro compounds 3 and 4.

Related Articles:

A simple method for the displacement of bromine by fluorine at tertiary, benzylic or non-classical secondary sites

[Leroux, Frederic; Garamszegi, Laszlo; Schlosser, Manfred Journal of Fluorine Chemistry, 2002 , vol. 117, # 2 p. 177 - 180]

Mild fluorofunctionalization of side chains in alkyl substituted aromatics by cesium fluoroxysulfate

[Stavber, Stojan; Zupan, Marko Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7347 - 7350]

Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1, 4-Ketoester followed by Carbonyl-Directed …

[Bellavance, Gabriel; Dube, Pascal; Nguyen, Bao Synlett, 2012 , # 4 p. 569 - 572]

Fluorodecarboxylation, rearrangement and cyclisation: the influence of structure and environment on the reactions of carboxylic acids with xenon difluoride

[Ramsden, Christopher A.; Shaw, Maxine M. Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3321 - 3324]

An easy access to fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazones

[Yadav, Arvind K.; Srivastava, Vishnu P.; Yadav, Lal Dhar S. Chemical Communications, 2013 , vol. 49, # 21 p. 2154 - 2156]

More Articles...