Simple and efficient method for N-Boc protection of amines using peg-400 as a reaction medium under mild conditions

H Zeng, Y Li, H Shao

Index: Zeng, Hongyao; Li, Yongjia; Shao, Huawu Synthetic Communications, 2012 , vol. 42, # 1 p. 25 - 32

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Citation Number: 3

Abstract

The protection of amines plays an essential role in synthetic organic chemistry and medicinal chemistry, especially peptide synthesis. [ 1 1. Greene , TW ; Wuts , PGM In Protecting Group in Organic Synthesis ; John Wiley and Sons : New York , 1999 . [CrossRef] View all references ] Out of the vast array of available amine protecting groups, the tert-butoxycarbonyl (Boc) group has emerged as the most commonly and widely used strategy because of ease of ...