Synthesis of aryl phosphates based on pyrimidine and triazine scaffolds

…, C Garbay, JC Florent, E Bertounesque

Index: Courme, Caroline; Gresh, Nohad; Vidal, Michel; Lenoir, Christine; Garbay, Christiane; Florent, Jean-Claude; Bertounesque, Emmanuel European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 244 - 255

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Citation Number: 12

Abstract

The syntheses of the triazinyl-based bis-aryl phosphates 2 and 3, and of the aminopyrimidyl- based aryl phosphate 4 are described. Each compound contains a diaryl ether-phosphate structural motif. The synthetic route to bis-aryl phosphates 2 and 3 consisted in two nucleophilic substitution reactions with amines from cyanuric chloride, followed by a Suzuki coupling with the resulting 2, 4-diamino-6-chloro-1, 3, 5-triazine derivative 12 to introduce ...