Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2, 6-difluorophenyl) alkyl]-3, 4-dihydro-5-alkylpyrimidin-4 (3 H)-ones as novel …

…, A Mai, G Sbardella, M Artico, S Massa…

Index: Sbardella, Gianluca; Mai, Antonello; Artico, Marino; Massa, Silvio; Marceddu, Tiziana; Vargiu, Laura; Marongiu, Maria Elena; La Colla, Paolo Medicinal Chemistry Research, 2000 , vol. 10, # 1 p. 30 - 39

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Citation Number: 91

Abstract

Dihydro-alkoxy-benzyl-oxopyrimidines (DABOs) are a family of potent NNRTIs developed in the past decade. Attempts to improve their potency and selectivity led to thio-DABOs (S- DABOs), DATNOs, and difluoro-thio-DABOs (F2-S-DABOs). More recently, we reported the synthesis and molecular modeling studies of a novel conformationally constrained subtype of the S-DABO series characterized by the presence of substituents on the methylene ...