Parallel solution-and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands

…, M De Boni, S Kolczewski, T Hoffmann…

Index: Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522

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Citation Number: 25

Abstract

The combination of the 3, 5-bis (trifluoromethyl) phenyl group with a spirohydantoin motive as a central scaffold was the basis for the design of a combinatorial library targeted towards the neurokinin-1 receptor. A solution-and solid-phase procedure is described and binding affinities of representative compounds presented.