Antituberculous activity of some aryl semicarbazone derivatives

D Sriram, P Yogeeswari, R Thirumurugan

Index: Sriram, Dharmarajan; Yogeeswari, Perumal; Thirumurugan, Rathinasabapathy Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3923 - 3924

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Citation Number: 46

Abstract

During the course of our work on the synthesis and screening of new drugs for tuberculosis, we have identified N1-(4-acetamido phenyl)-N4-(2-nitro benzylidene) semicarbazone (1b), which inhibited in vitro Mycobacterium tuberculosis H37Rv; 100% inhibition at 1.56 μg/mL. This paper is first of its kind in which aryl semicarbazones are reported to possess antimycobacterials potency greater than p-aminosalicylic acid, ethionamide, ethambutol, ...