Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5??Phenyl??2??Furan

ZN Cui, YX Shi, JR Cui, Y Ling, BJ Li…

Index: Cui, Zi-Ning; Shi, Yan-Xia; Cui, Jing-Rong; Ling, Yun; Li, Bao-Ju; Yang, Xin-Ling Chemical Biology and Drug Design, 2012 , vol. 79, # 1 p. 121 - 127

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Citation Number: 10

Abstract

A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1, 3, 4-triazole (series II) was higher than that of pyrazoleattached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than ...