J. Org. Chem

Convenient Synthetic Route to an Enantiomerically Pure FMOC#-Amino Acid

DF Taber, JF Berry, TJ Martin

Index: Taber, Douglass F.; Berry, James F.; Martin, Timothy J. Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9334 - 9339

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Citation Number: 8

Abstract

A strategy for the facile R-amination of carboxylic acid menthyl esters is described. The resulting diastereomers, readily separable, can be individually carried on to each enantiomer of the FMOC R-amino acid. A variety of unnatural side chains were compatible with this approach. The menthyl ester was easily removed from the FMOC R-amino acid without racemization.

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