A method for the synthesis of racemic and optically active 2??substituted 9??(2′, 3′??dihydroxypropyl)??8??azahypoxanthines and 8??azaadenines
…, G Biagi, I Giorgi, O Livi, V Scartoni
Index: Barili; Biagi; Giorgi; Livi; Scartoni Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1351 - 1355
Full Text: HTML
Citation Number: 12
Abstract
Abstract Several 9-(2′, 3′-O-isopropylidene)-and 9-(2′, 3′-dihydroxypropyl)-8- azahypoxanthines and 8-azaadenines were synthesized by a “one pot” method starting from the acetonide of racemic or (S)-1-azido-2, 3-dihydroxypropane, obtained from D-mannitol. 9- (2′, 3′-Dihydroxypropyl)-8-azapurines were tested as adenosine deaminase inhibitors.
Related Articles:
Asymmetric synthesis of orthogonally protected (2S, 4R)-and (2S, 4S)-4-hydroxyornithine
[Lepine, Renaud; Carbonnelle, Anny-Claude; Zhu, Jieping Synlett, 2003 , # 10 p. 1455 - 1458]
[Ganesan; Muraleedharan Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 2 p. 91 - 96]
[Ganesan; Muraleedharan Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 2 p. 91 - 96]