Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics

H Schönenberger, A Adam

Index: Schoenenberger,H.; Adam,A. Arzneimittel Forschung, 1965 , vol. 15, p. 30 - 36

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Abstract

cf. CA 63, 5474c. The growth of Ehrlich ascites tumor in mice was inhibited by mono-and dialkylthiomethylamine derivs., which react with the higher H+ concn. in tumor cells to give carbonium-immoninm ions which alkylate the substrate. The low toxicity of these compds. ...