Stabilisation of peptide foldamers in an aqueous medium by incorporation of azapeptide building blocks

…, C Somlai, E Vass, TA Martinek, F Fülöp

Index: Hetenyi, Anasztazia; Toth, Gabor K.; Somlai, Csaba; Vass, Elemer; Martinek, Tamas A.; Fueloep, Ferenc Chemistry - A European Journal, 2009 , vol. 15, # 41 p. 10736 - 10741

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Citation Number: 30

Abstract

Foldamers stabilised by long-range H-bonding interactions constitute a thoroughly studied class of protein-mimicking materials and are currently attracting considerable interest.[1] There are two major approaches to the modification of natural α-amino acid building blocks: 1) homologation of the amino acid residues (this results in aliphatic β-and gpeptides [2] and aromatic oligoamide foldamers)[3] and 2) replacement of the amide moiety with functional ...

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