Design and syntheses of anti-tuberculosis agents inspired by BTZ043 using a scaffold simplification strategy

…, S Cho, SG Franzblau, PA Miller, MJ Miller

Index: Tiwari, Rohit; Moraski, Garrett C.; Krchnak, Viktor; Miller, Patricia A.; Colon-Martinez, Mariangelli; Herrero, Eliza; Oliver, Allen G.; Miller, Marvin J. Journal of the American Chemical Society, 2013 , vol. 135, # 9 p. 3539 - 3549

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Citation Number: 6

Abstract

Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), is a global public health concern because of the emergence of various resistant strains. Benzothiazin-4-ones (BTZs), represented by BTZ043, are a promising new class of agents for the treatment of tuberculosis and have been shown to kill Mtb in vitro, ex vivo, and in mouse models of TB. Herein we report the design and syntheses of nitroaromatic sulfonamide, reverse-amide, ...