Candida antarctica lipase B-catalyzed reactions of β-hydroxy esters: Competition of acylation and hydrolysis
E Forró, Z Galla, F Fülöp
Index: Forro, Eniko; Galla, Zsolt; Fueloep, Ferenc Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 98, p. 92 - 97
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Citation Number: 4
Abstract
Abstract The ester function of ethyl cis-(±)-2-hydroxycyclopentane-1-carboxylate [(±)-1] and ethyl (±)-5-hydroxycyclopent-1-enecarboxylate [(±)-2] was demonstrated to undergo hydrolysis, as a side-reaction, during asymmetric (E> 200) O-acylation with Candida antarctica lipase B (CAL-B) as catalyst and vinyl acetate as acyl donor in t-BuOMe at 30 C. This competition of acylation and undesirable hydrolysis draws attention to CAL-B- ...
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[Journal of Molecular Catalysis B: Enzymatic, , vol. 98, p. 92 - 97]