Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site

…, H Diaz Arauzo, MS Allen, AJ LaLoggia…

Index: Martin; Trudell; Arauzo; Allen; LaLoggia; Deng; Schultz; Tan; Bi; Narayanan; Dorn; Koehler; Skolnick; Cook Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4105 - 4117

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Citation Number: 44

Abstract

Since the introduction of Librium in 19601 and the subsequent discovery in 19772* 3 of its mode of action via the 7-aminobutyric acid (GABA)/benzodiazepine receptor (BzR) system, the benzodiazepines have enjoyed widespread use rivaled by few other classes of compounds. Benzodiazepine agonists effect a variety of pharmacological actions, but are far less toxic than, for example, barbiturates. Benzodiazepine receptor ligands produce their ...