Tetrahedron letters

Regiospecific intramolecular ring-closure of heterocumulene-substituted indoles: Formation of γ-carbolines and pyrimido [3, 4-a] indoles

P Molina, J Alcantara, C Lopez-Leonardo

Index: Molina, Pedro; Alcantara, Julian; Lopez-Leonardo, Carmen Tetrahedron Letters, 1995 , vol. 36, # 6 p. 953 - 956

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Citation Number: 12

Abstract

2-(Indol-2-yl) ethyl heterocumulenes undergo ring-closure under acid, basic and thermal conditions to give either dihydro γ-carbolines or dihydropyrimido [3, 4-a] indoles in a completely regiospecific fashion. The mode of cyclization strongly depends on the cyclizating agent as well as the nature of the heterocumulene.