The total synthesis of prostaglandins by the tropolone route

AE Greene, MA Teixeira, E Barreiro…

Index: Greene, Andrew E.; Teixeira, Marco A.; Barreiro, Eliezer; Cruz, Alicia; Crabbe, Pierre Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2553 - 2564

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Citation Number: 33

Abstract

Method A. The crude product was chromatographed with 5100 (v/v) ether/hexane to give 127 mg (51%) of 15 as a colorless solid mp 132.2-132.7 OC (lit.'lb mp 134-135" C); IR (CHCl,) 1667, 2128 cm-'; NMR (CDCl,) 6 0.36 (8, 9, SiMe3), 8.32 (s, 4, p-0, NPh). 5 4 (tert- Butyldimethylsilyl) oxy]-3-pentyn-2-one (16).